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Oral bioavailability (f%) is the fraction of an oral administered drug that reaches systemic circulation. After intravenous administration, a drug is directly. Bioavailability is expressed as the percentage of the total drug dose administered that reaches the circulation. For a drug taken orally, the ‘first-pass effect. Oral drugs have slower absorption and distribution than iv drugs. The amount of drug that is absorbed can depend on the status of the gi tract. Bioavailability is expressed as ba% or f in this book. In the case of oral absorption, f is usually defined based on the total amount of a drug that reached. Because oral administration is convenient and does not damage the skin or mucous membranes, 80% of the world’s drugs are administered orally [3]. A drug is known to be highly permeable if the percentage of absorption is ≥90% of the administered dose. Bcs class i drugs have high solubility. In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. Bioavailability refers to the extent and rate at which the active moiety (drug or metabolite) enters systemic circulation, thereby accessing the site of action. Bioavailability refers to the extent a substance or drug becomes completely available to its intended biological destination(s)
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